Two randomized controlled trials (RCTs) towards optimization of pharmacotherapy in old patients, the SENATOR and OPERAM study, are well in progress. The SENATOR study have included about 200 patients and the OPERAM study will start the inclusion period on time in December. The RCTs use software supported methods, which include also the STOPP/START criteria. The aim of the studies is to avoid the prescription of inappropriate medicines and avoidable adverse drug reactions.

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