The second OPERAM meeting will take place at 11 and 12 January 2016 in Bunnik close to Utrecht. During this meeting the set up of the OPERAM trial and especially the use of the new version of the STRIPassistant, the implementation of the medication review and adjudication of adverse effects will be discussed. Also the health economics part of the trial and the performance of the systematic reviews and network meta-analysis are topics at this meeting.